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Biochemistry Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico The female breast represents the center of femininity and constitutes one of the most important physical and psychological elements in a woman. It is characterized by a diverse anatomy that comprises different volumes, width, height, projection, composition, shape, and position in the chest wall. She felt more confident in an off-the-shoulder top that she usually has to wear with the sleeves up to cover her bra straps.

Villarreal-Garza, C. et al. Molecular subtypes and prognosis in young mexican women with breast cancer. Clin. Breast Cancer 17, e95–e102 (2017). The sample was subdivided by decade of age in 4 groups: 3 rd decade, 4 th decade, 5 th decade > 6 th decade of life. And taking into consideration that breast size increases by 20 cc for every kg above the ideal body weight (BMI: 18.5 - 24.9 Kg/m 2), groups were also subdivided by BMI. Demographic information collected included: age, heigh, weight, BMI (Kg/m 2). Yaeger, R. et al. Clinical sequencing defines the genomic landscape of metastatic colorectal cancer. Cancer Cell 33, 125–136 (2018). e123.Roberts, S. A. et al. An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers. Nat. Genet. 45, 970–976 (2013).

Lefebvre C, et al. Mutational Profile of Metastatic Breast Cancers: A Retrospective Analysis. PLoS Med 13, e1002201 (2016). Mermel, C. H. et al. GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers. Genome Biol. 12, R41 (2011). only one value (Nipple areola complex diameter). The mean values for Nipple areola complex diameter divided by age group were: 3rd decade of life (R 3.9 cm, I 3.9 cm), Fourth decade of life (R 4.1 cm, I 4.2 cm), Fifth decade of life (R 4.4 cm, I 4.3 cm), >6 th decade of life (R 3.9 cm, I 3.9 cm) ( Figure 6). The mean value established for NAC diameter was 4.1 cm, without any statistically significant difference in age group or side (p < 0.414) ( Table 4). Comparing the values found in this study to the aesthetically ideal breast described by Malluci, we observe that our measurements fall far from what is considered ideal breast proportion [2] [7] ( Table 6). As mentioned previously this correlates with our findings in everyday practice, where we have detected an important prevalence of tuberous breasts. To standardize measurements, first from a front view a horizontal line at the level of the nipples is drawn (Horizontal nipple plane), then a vertical line is drawn from the nipple to the inframammary fold (Lower breast pole length). From a lateral view a horizontal line is drawn at the breaking point where the breast starts from the chest wall (superior breast limit). The upper breast pole is described as the area between the superior breast limit and the horizontal nipple plane. The lower breast pole is described as the area between the nipple and the Inframammary Fold (IMF). The proportion of each breast pole was established by diving the length of each pole by the sum of the vertical distance, over the breast, between the superior limit and the inframammary fold at the level of the nipple, and then multiplied by 100 (LBPL/(LBPL + UBPL) * 100).This study was reviewed and approved by the HCSAE’s Research and Ethics committee. All the measurements were taken from volunteering women from July to October 2021. The sample size was based on previous similar studies in another population, using simple random sampling. Breast Anthropometric measurements were performed in a total of 100 patients. 22 patients were excluded because they did not fulfill previously mentioned criteria. A total of 78 female Mexican volunteers aged between 20 to 60 years old were considered for this study. With the current state of events, celebrating women's bodies is as important as ever. But for BAZAAR, championing curves of every size has always been a priority. As we reflect on some of the best breast moments in the title's history, both understated and overt, it has become clearer with every shot that the feminine anatomy, no matter which way that you look at it, is a work of art. Although TMB is one of the main factors that characterizes cancer genomes and a potential marker of risk assessment, there are also particular mutational processes that generate unique signatures and, along with TMB, constitute emergent informative features of cancer. Therefore, we investigated which mutational signatures operate in HM tumors and their association with age and subtype prevalence. To gain further insights into these operative mutational processes, the contribution of mutational signatures were delineated using deconstructSigs 18 and SigFit 19 tools based on single nucleotide variations (SNV) in tumors harboring a TMB above the median value for each tumor collection ( n = HM 69, 52 AA, 30 Asian, 323 Caucasian, Asian Kan 94). The mutational landscape of each signature deconstructed by the two algorithms showed a highly concordant result (Supplementary Fig. 5a). Most individual cancer exomes exhibit more than one mutational signature (Sig) and many different combinations of signatures were observed among BC tumors, across all populations (Supplementary Fig. 5b). In general, 8 signatures were robustly detected among BC tumors from the 30 COSMIC signatures v2 20, but it seems that some tumors have a more complex repertoire of mutational processes than others (Supplementary Fig. 5b, Supplementary Data 4). Top frequently mutated signatures among patients from different ancestry deconstructed with both algorithms included: Sig1, Sig2, Sig3, Sig13 and Sig7 (Fig. 3c, Supplementary Fig. 5c, d, and Supplementary Data 4). Of note, 96% of the evaluated tumors presented one of these top signatures, while the remaining 4% did not present any of them.